PSC2122 - Synthetic organic chemistry - 2018

This subject aims to provide students with an understanding of:

1. The use of functional groups in carbon-carbon and carbon-heteroatom bond formation;
2. The fundamentals of molecular orbitals in pericyclic reactions;
3. The preparation and use of organometallic in organic synthesis.The synthesis of organic molecules, including naturally occurring bioactives and other drug molecules.

   This will involve:

   • functional group manipulation .The chemistry of organometallic reagents.
   • pericyclic chemistry
   • synthesis of heterocycles
   • reactions of aromatic heterocycles
   • synthesis of heterocyclic drugs

At the end of this unit students will be able to:

1. Draw mechanisms and rationalise the outcome of a range of functional group manipulations;
2. Rationalise the use of functional groups in organic synthesis;
3. Understand the use of organometallic reagents in synthesis and their reaction mechanisms;
4. Understand the role of molecular orbitals in pericyclic reactions;
5. Apply knowledge of organometallic, pericyclic and heterocyclic reactions to the design of synthetic routes for preparing simple organic compounds.

Final exam (2 hour): 50%; Mid-semester assessments: 20%; Practical assessments: 20%; Practical exam:10%.

Contact hours for on-campus students:

• Twenty 1-hour lectures
• Ten 1-hour whole class workshops / active learning sessions
• Nine 4-hour laboratory practical exercises, including practical exam

Additional requirements:

• Twelve hours practical report preparation

See also Unit timetable information

http://www.monash.edu/pharm/current/