6 points, SCA Band 2, 0.125 EFTSL
Undergraduate - Unit
Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.
Faculty
Pharmacy and Pharmaceutical Sciences
Chief examiner(s)
Coordinator(s)
Unit guides
Prerequisites
PSC1011
PSC1012
Synopsis
This unit builds upon previous learning related to physiology and physical chemistry to provide the student with an understanding of factors affecting absorption of drugs following oral administration and alternative routes of delivery. This unit introduces students to pharmacokinetics and how this may be affected by formulation design and route of administration.
This will involve:
- oral drug absorption
- pharmacokinetics
- bioavailability
- parenteral formulations
- alternative routes of drug delivery
Outcomes
At the end of this unit students will be able to:
- Discuss the physiological and physicochemical factors affecting drug absorption across the small intestine;
- Define and calculate pharmacokinetic parameters, including drug clearance, elimination half-life, volume of distribution, fraction unbound and fraction excreted unchanged in urine;
- Calculate predicted plasma concentrations of drugs given the pharmacokinetic parameters of the drug;
- Define bioavailability and estimate the absolute and relative bioavailability of drugs given plasma concentration data;
- Understand the physical, chemical and biological factors affecting parenteral drug delivery;
- Understand formulation techniques for poorly water soluble drugs;
- Discuss the factors affecting drug delivery to the eye, buccal cavity, nasal cavity, skin, lungs, vagina and rectum.
Assessment
Final exam (2 hour): 60%; mini-exams: 30%; debate: 10%.
Workload requirements
Contact hours for on-campus students:
- Twenty seven 1-hour lectures
- Four 2-hour workshops
- One 3-hour workshop
See also Unit timetable information