Bachelor of Pharmaceutical Science - 2018

In this course you will learn about the chemistry, biology and technology of medicines and other chemical formulations and how to improve human health and well-being by researching and developing more reliable, accessible and effective treatments and products. You will develop the knowledge and practical skills critical to the discovery and development of new drugs and therapies leading to exciting careers in research and industry.

During the first two years you will develop your understanding of the foundations of pharmaceutical science and of the relationships between the different disciplines and their distinct roles in drug discovery and development. This will prepare you to choose your specialisation from one of the following fields:

• Drug discovery biology: the discovery and understanding of biological drug targets, and their modulation by chemicals and other substances.
• Formulation science: the invention, manufacture and testing of new products such as pharmaceuticals, food and cosmetics.
• Medicinal chemistry: the principles and techniques behind drug discovery and development.

You will then develop specialist knowledge and techniques and your understanding of the application of pharmaceutical methods and professional practices required in the workplace. You will study with one of the largest and most productive groups of pharmaceutical researchers in Australia, the Monash Institute of Pharmaceutical Sciences, and you will graduate having worked in industry-standard facilities, such as our Shimadzu high-pressure liquid chromatography (HPLC) lab.

In your final year you will gain practical skills through a major research project or industry placement and be ready for a career in pharmaceutical research, the biomedical industry and many other fields that require advanced chemical-formulation skills. Drug discovery biology will prepare you for a career in translating the information and outcomes of drug development studies into pharmaceutical products. Formulation science will prepare you for a range of careers in developing pharmaceuticals, food, cosmetics, agricultural chemicals, veterinary products, paints and inks and many other consumer goods. Medicinal chemistry will prepare you for a range of industrial, academic and commercial career paths.

Double degrees

The Bachelor of Pharmaceutical Science course, with the formulation science specialisation, can be taken in combination with the following course:

• Bachelor of Engineering (Honours) (Chemical engineering specialisation only)

This will lead to the award of two degrees, the Bachelor of Pharmaceutical Science and the Bachelor of Chemical Engineering (Honours). The requirements for the award of each of the degrees will be fulfilled in part by cross crediting of units required in the separate courses. Students should refer to the course entry for the Bachelor of Engineering (Honours) for the requirements for the chemical engineering specialisation.

Specialisations

Drug discovery biology

This field focuses on the biomedical science and pharmacology of drug discovery, with an understanding of biological drug targets, and their modulation by all types of active drug compounds. It explores the biotechnological aspects of drug design and evaluation, including discovering and evaluating new targets for testing drugs; the biological effects of drug candidates; and translating outcomes into pharmaceutical products.

Formulation science

This field involves formulating, designing and evaluating pharmaceuticals and other products and explores the transformation of the active drug compounds into a finished product. This includes design, generation and evaluation of new pharmaceutical products and applications beyond, such as foods and personal products.

Medicinal chemistry

This field is at the intersection of biology and chemistry and involves the study of how drugs work and how they are designed and made. Medicinal chemistry applies the principles and techniques of chemistry to discover and develop compounds that prevent, treat or cure disease. It's a feedback process of design, synthesis and biological testing to optimise the potency, selectivity and absorption in the body of a compound, while minimising side effects.

These course outcomes are aligned with the Australian Qualifications Framework level 7 and Monash Graduate AttributesAustralian Qualifications Framework level 7 and Monash Graduate Attributes (http://www.monash.edu.au/pubs/handbooks/alignmentofoutcomes.html).

Upon successful completion of this course, it is expected that students will be able to:

1. demonstrate well-developed knowledge of pharmaceutical science, and advanced knowledge of a specialised discipline within the field of one of the specialisations: drug discovery biology, formulation science or medicinal chemistry. In particular:
   • drug discovery biology specialists will appreciate the mechanisms of drug action based on interactions at molecular, cellular and organ level, identify the appropriate research methods required for the evaluation of new drug targets, and evaluate candidate novel therapeutic agents based on affinity/efficacy profiles
   • medicinal chemistry specialists will understand and apply the principles of drug action, design and implement approaches to synthesising bioactive molecules, and analyse chemical structures and interactions using computational, spectroscopic and analytical techniques
   • formulation science specialists will be capable of designing drug delivery systems for all types of active molecules, understand processes that contribute to the product life cycle, possess analytical skills to assess the physical, and chemical properties of active molecules and delivery systems, and have knowledge to evaluate the suitability of these formulations within the context of industrial and regulatory environments
2. demonstrate well-developed skills in the methods and processes of pharmaceutical science
3. make valid judgements through critical thinking, and synthesise information from a range of sources to provide relevant solutions to scientific problems
4. communicate effectively in a variety of modes, to diverse audiences and for a range of purposes
5. think globally and consider pharmaceutical issues from a variety of perspectives, and apply international standards for research practices in pharmaceutical sciences
6. work safely and effectively, both independently and in multi-disciplinary teams
7. demonstrate leadership, and professional and ethical behaviour.

The course develops through three themes. The first two, foundation science studies and pharmaceutical science studies culminate in an applied project.

Part A. Foundation science studies

Foundation studies in bio-organic and medicinal chemistry, physical chemistry and physiology will underpin further studies in your chosen specialisation. It will also provide an introduction to the key areas of scientific communication and practice and scientific research methodology.

Part B. Pharmaceutical science

This will provide you with practical and theoretical skills and knowledge of your specialisation. You will learn to develop, apply and communicate the concepts and theoretical frameworks that constitute the knowledge base of your chosen discipline.

Part C. Applied project

The studies in parts A. and B. culminate in a major research project or industry placement.

The course comprises 144 points of pharmaceutical science study.

The course develops through theme studies in: A. Foundation science, B. Pharmaceutical science and C. Applied project.

The course progression mapcourse progression map (http://www.monash.edu.au/pubs/2018handbooks/maps/map-p2001.pdf) will assist you to plan to meet the course requirements and guidance on unit enrolment for each semester of study.

Units are 6 credit points unless otherwise stated.

Common first four semesters (96 points)

Part A. Foundation sciences

Students complete:

• BPS1011 Human physiology I: Cells to systems
• BPS1021 Medicinal chemistry I: Structure
• BPS1031 Physical chemistry I: Equilibria and change
• BPS1012 Human physiology II: Body systems
• BPS1022 Medicinal chemistry II: Reactivity and biomolecules
• BPS1032 Physical chemistry II: Solutions, surfaces and solids
• BPS2011 Pharmacology I: Biochemical signalling*
• BPS2021 Synthetic chemistry I*
• BPS2031 Analytical methods I: Principles and applications
• BPS2041 Drug delivery: Absorption pathways
• BPS2012 Pharmacology II: Drug action*
• BPS2032 Analytical methods II: Investigation design*

* Students in E3008 Bachelor of Engineering (Honours) and Bachelor of Pharmaceutical Science do not complete these units since the chemical engineering studies provide the knowledge and skills.

Part B. Pharmaceutical science

Students complete:

• BPS1041 Scientific inquiry
• BPS1042 Pharmaceutical science in context
• BPS2022 Drug discovery and design
• BPS2042 Drug development

Specialist drug discovery biology study (48 points)

Part B. Pharmaceutical science and Part C. applied project

Students complete:

• BPS3111 Pharmacology III: Advanced concepts
• BPS3121 Disease focused pharmacology - peripheral
• BPS3131 Microbiology and immunology
• BPS3112 Professional experience in drug discovery biology
• BPS3122 Disease focused pharmacology - CNS
• BPS3132 Toxicology

and two of the following units:

• BPS3211 Computational drug design
• BPS3321 Biotechnology products
• BPS3311 Applied pharmacokinetics and pharmacodynamics
• BPS3711 Analysis of drug-receptor interactions
• BPS3232 Molecular basis of drug action
• BPS3322 Drug delivery nanotechnology

Specialist formulation science study (72 points)

Part B. Pharmaceutical science and Part C. Applied project

Students complete:

• BPS3311 Applied pharmacokinetics and pharmacodynamics*
• BPS3321 Biotechnology products
• BPS3331 Pharmaceutical product development and manufacture
• BPS3312 Professional experience in formulation science*
• BPS3322 Drug delivery nanotechnology
• BPS3332 Industrial formulation

and two of the following units: *

• BPS3121 Disease focused pharmacology - peripheral
• BPS3131 Microbiology and immunology
• BPS3211 Computational drug design
• BPS3711 Analysis of drug-receptor interactions
• BPS3122 Disease focused pharmacology - CNS
• BPS3132 Toxicology
• BPS3232 Molecular basis of drug action

* Students in E3008 Bachelor of Engineering (Honours) and Bachelor of Pharmaceutical Science do not complete these units since the chemical engineering studies provide the knowledge and skills.

Specialist medicinal chemistry study (48 points)

Part B. Pharmaceutical science and Part C. applied project

Students complete:

• BPS3211 Computational drug design
• BPS3221 Synthetic chemistry II: Emerging methods
• BPS3231 Advanced experimental spectroscopy
• BPS3212 Professional experience in medicinal chemistry
• BPS3222 Synthetic strategies for drug design
• BPS3232 Molecular basis of drug action

and two of the following units:

• BPS3121 Disease focused pharmacology - peripheral
• BPS3131 Microbiology and immunology
• BPS3321 Biotechnology products
• BPS3711 Analysis of drug-receptor interactions
• BPS3122 Disease focused pharmacology - CNS
• BPS3132 Toxicology
• BPS3322 Drug delivery nanotechnology

Students successfully completing the Bachelor of Pharmaceutical Science may proceed to a one year honours program leading to the Bachelor of Pharmaceutical Science (Honours). To be eligible to apply for entry into P3701 Bachelor of Pharmaceutical Science (Honours), students must achieve an overall distinction grade average (70 per cent) or higher in the final year of the course.