6 points, SCA Band 2, 0.125 EFTSL
Undergraduate - Unit
Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.
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Synopsis
The unit examines the pathways by which cells receive external information and process this into specific biochemical responses. We begin with a survey of different mechanisms of cellular signalling and their roles in 'normal' cellular activities and overall homeostasis. A diverse set of cellular processes is studied and the normal control mechanisms highlighted. This is followed by investigation of the dysfunction of signalling mechanisms in several disease states. Topics covered are: the cell cycle, apoptosis, haematopoiesis, atherosclerosis and HIV/AIDS. The aim is to demonstrate to students that dysfunction or inappropriate cellular signalling plays a key role in the pathogenesis of many common disease. Methods of clinical diagnosis are introduced and incorporated into the laboratory work, which is designed to illustrate concepts of the theory.
Outcomes
On completion of this unit students will be able to:
- Describe a range of cellular signalling mechanisms;
- Explain endocrine control of cellular processes;
- Discuss the dysfunction of cell signalling mechanisms in several common disease states;
- Discuss the role of biochemical and spectroscopic techniques in the diagnosis of disease;
- Plan and execute complex biochemical laboratory procedures and interpret data acquired;
- Demonstrate basic competence in the safe handling of hazardous biological materials.
Assessment
Examination (2 hours): 50%
Major assignment (5000 words): 20%
Practical work: 30%
Workload requirements
Three hours of lectures per week and 40 hours laboratory work per semester
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