PSC3122 - Applied Medicinal Chemistry - 2019

In this unit students will learn how chemical synthesis is applied to drug discovery and Chemical-Biology. Topics will include compound library design and synthesis, mapping of structure-activity relationships, lead optimization, molecular conjugates, asymmetric synthesis and processes chemistry.

These will be taught as four core topic areas: This unit will build upon earlier units in synthetic organic chemistry within BPharmSci, with a special emphasis on the role of chemical synthesis in drug discovery and Chemical-Biology. This will include library design approaches for the discovery of novel bioactives and synthesis strategies in lead optimization. Students will learn about the use of conjugates in directed drug delivery and Chemical-Biology studies. They will also learn about the specific challenges posed by the scale-up and manufacture of drugs including the asymmetric synthesis of chiral drug molecules. In laboratory classes, students will learn new and emerging techniques for use in compound library synthesis and process chemistry. Site visits of relevant commercial operations will also be undertaken.

Students will have learnt:

1. The key parameters used in the design of libraries for use drug-discovery and Chemical-Biology.
2. How to map structure-activity relationships and their role in lead optimization.
3. How to undertake the asymmetric synthesis of drug molecules
4. The key requirements of drug scale-up and manufacture
5. The role of drug conjugates in site-directed drug delivery and Chemical-Biology studies
6. To use emerging technologies in laboratory equipment (flow and microwave reactors)
7. How to separate reaction products using modern chromatographic techniques

Four assessable quizzes during semester (5% each): 20%; End of semester exam: Outcomes 60%; Practical reports / workshop assignments: 20%

Contact hours for on-campus students:

• Thirty six 1-hour lectures /active learning sessions and workshops
• Four 6-hour laboratory classes
• One-two Site visits (4-8 hours)

See also Unit timetable information

http://www.monash.edu/pharm/current/