6 points, SCA Band 2, 0.125 EFTSL
Undergraduate - Unit
Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.
- Second semester 2019 (On-campus)
Human Physiology II: Body systems
Unit previously coded PSC2012
Pharmacology II will introduce students to advanced concepts related to drug action, including descriptions of antagonist activity, partial and inverse agonists, allosteric modulators and biased ligands. This unit also extends beyond drug-receptor interactions to show how signal transduction processes regulate cellular activities. The gastrointestinal system will be used as an exemplar to demonstrate how the normal physiological function of an organ system can be used to define mechanisms of disease and allow for the identification of suitable drug targets.
Students will practice laboratory techniques and experimental approaches to solving pharmacological research questions. They will also record, interpret and communicate the outcomes of such investigations to a variety of audiences.
Topics to be covered include:
- Characteristics of drug interaction with receptors (agonist and antagonist quantitation);
- Properties of G-protein coupled receptors and interactions with signal transduction systems;
- Ion channels, transporters and intracellular calcium signalling.
At the end of this unit students will be able to:
- Describe how pharmacologically active chemicals might affect living systems through interactions with receptors;
- Speculate upon the nature of drug action at receptors and likely intracellular signalling mechanisms;
- Explain how receptor-mediated changes in intracellular calcium might regulate specific bodily functions;
- Use our understanding of drug action at a cellular level to predict drug effects upon human health;
- Record, analyse and critically interpret experimental data and report it in written and visual formats.
End-of-semester examination (50%) and in-semester assessment (50%)
- Twelve 1-hour online modules (discovery)
- Twenty-four 1-hour lectures
- Thirty-six hours of laboratory classes and workshops
See also Unit timetable information