PSC2122 - Synthetic organic chemistry - 2017

6 points, SCA Band 2, 0.125 EFTSL

Undergraduate - Unit

Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.


Pharmacy and Pharmaceutical Sciences


Associate Professor Bernard Flynn

Unit guides



  • Second semester 2017 (Day)


This subject aims to provide students with an understanding of:

  1. The use of functional groups in carbon-carbon and carbon-heteroatom bond formation;
  2. The fundamentals of molecular orbitals in pericyclic reactions;
  3. The preparation and use of organometallic in organic synthesis.The synthesis of organic molecules, including naturally occurring bioactives and other drug molecules.

    This will involve:

    • functional group manipulation .The chemistry of organometallic reagents.
    • pericyclic chemistry
    • synthesis of heterocycles
    • reactions of aromatic heterocycles
    • synthesis of heterocyclic drugs


At the end of this unit students will be able to:

  1. Draw mechanisms and rationalise the outcome of a range of functional group manipulations;
  2. Rationalise the use of functional groups in organic synthesis;
  3. Understand the use of organometallic reagents in synthesis and their reaction mechanisms;
  4. Understand the role of molecular orbitals in pericyclic reactions;
  5. Apply knowledge of organometallic, pericyclic and heterocyclic reactions to the design of synthetic routes for preparing simple organic compounds.


Final exam (2 hour): 50%; Mid-semester assessments: 20%; Practical assessments: 20%; Practical exam:10%.

Workload requirements

Contact hours for on-campus students:

  • Twenty 1-hour lectures
  • Ten 1-hour whole class tutorials / active learning sessions
  • Nine 4-hour laboratory practical exercises, including practical exam

Additional requirements:

  • Twelve hours practical report preparation

See also Unit timetable information

Chief examiner(s)


Additional information on this unit is available from the faculty at: