6 points, SCA Band 2, 0.125 EFTSL
Undergraduate - Unit
Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.
- Second semester 2017 (Day)
CHM2942 has been designed for students from chemical and biological backgrounds who have a strong, common interest in the chemistry of living systems. In this unit students will be able to apply their knowledge by examining chemical processes in a biological context: the relationship between stereochemistry and biological activity; transition states of enzyme catalysed reactions; molecular mechanisms underlying glycoside bond formation and breakage; describe the chemical reactivity of organic and inorganic molecules and the reactions occurring at different functional groups; develop a basic understanding of bio-conjugate chemistry and its applications; classical and contemporary bioinorganic chemistry of metals; metal coordination chemistry; molecular mechanisms for redox potentials within living systems; metalloproteins and co-enzymes; transport and storage of naturally occurring and toxic metals; role of metals in medicine; applications of modern bio-spectroscopic and bio-imaging techniques; visualisation and monitoring of chemical processes occurring in living tissues; processing bio-imaging and bio-spectroscopic data.
On completion of this unit students will be able to:
- Add to their understanding of the chemical reactivity of organic molecules and the relationship between stereochemistry and biological activity;
- Understand the concept of a transition state in enzyme-catalyzed reactions and the difference between inverting and retaining mechanisms in carbohydrate processing enzymes;
- Apply the concept of protective groups in organic chemistry for the synthesis of carbohydrates and glycoconjugates;
- Understand and describe the physical and chemical behaviour of metal ions in aqueous solution, particularly in relation to formation, stability and ligand lability;
- Understand the role of metals in biology, and the development and application of metal-based therapeutics and diagnostics;
- Apply an understanding of the use of spectroscopic techniques for determining the structure and function of biomolecules;
- Understand the different types of bio-imaging techniques and the methods used to process bio-imaging data.
Examination (2 hours): 50% (Hurdle)
Mid-semester test (45 mins): 20%
Laboratory work: 30% (Hurdle)
Hurdle requirement: To pass this unit a student must achieve a minimum score of 50% in the laboratory practical component and a minimum of 30% for the end-of-semester exam.
Three 1-hour lectures per week, a one hour workshop/tutorial every fortnight, and four hours laboratory activity for 10 weeks
See also Unit timetable information