BCH3052 - Protein biology: From sequence to structure and disease - 2017

6 points, SCA Band 2, 0.125 EFTSL

Undergraduate - Unit

Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.




Associate Professor Jackie Wilce

Unit guides



  • Second semester 2017 (Day)


The course will give students an advanced understanding of protein structure-function in the context of human disease. Major themes relate the various levels of protein structure to their wide ranging functions, introduce modern techniques used in the analysis of structure and function, and explore the rapidly developing area of protein-related biotechnologies and drug design. Topics to be covered include examples of aberrations in protein structure that lead to alteration in function in a variety of biological contexts, emphasizing disease. Additionally the use of bioinformatics in aiding our understanding of protein sequence, structure and function will be highlighted.


On completion of this unit students will be able to:

  1. Describe the relationship between protein sequence, structure and function and relate this to specific examples in human health and disease;
  2. Explain how proteins fold to their correct three dimensional shape and how this process may go wrong and cause disease;
  3. Illustrate how NMR and X-ray crystallography are used to determine the structure of a peptide or protein;
  4. Critically analyse how our understanding of proteins contributes to biotechnology and medicine, in particular comment on the contribution of protein engineering and proteomics to these fields;
  5. Describe the use of fluorescent proteins as tools for characterising the role of proteins in vivo;
  6. Apply experimental techniques and methodologies to determine the structure and function of an unknown protein.


Examination (2 hours): 60% (Hurdle)

  • Practical theory test: 10% (Hurdle)
  • Practicals: 30% (Hurdle)

This unit is subject to the Hurdle and Threshold Standards policiesHurdle and Threshold Standards policies (http://www.med.monash.edu.au/policies/assessment-policy-2017.html) of the Faculty of Medicine, Nursing & Health Sciences.

Workload requirements

Two hours of lectures and four hours of laboratory or tutorial sessions per week

See also Unit timetable information

Chief examiner(s)

This unit applies to the following area(s) of study


One of BCH2011, BCH2022, MOL2011, MOL2022, MCB2011, MCB2022 or BMS2021 or BMS2062