VPS3011 - Synthetic medicinal chemistry

Leader(s): Dr Jamie Simpson

Offered

Parkville First semester 2009 (Day)

Synopsis

The principle aim of this subject is to provide students with a detailed knowledge of numerous aspects of synthetic organic chemistry, as it applies to modern medicinal chemistry.

Objectives

The subject follows from BMC2021 and BMC2022, covering advanced organic synthesis and methodology. Topics include catalysis in synthesis, radical chemistry, organometallic chemistry, heterocyclic chemistry, reactive intermediates and stereochemistry, as well as retrosynthetic analysis. An understanding of reaction mechanisms will be emphasized throughout. The practical component reinforces aspects of the lecture course with laboratory experience. At the completion of this unit, students will have:

1. A wider knowledge of synthetic methodology;
2. A knowledge of the use of catalysis in synthetic chemistry;
3. An understanding of radical reactions and their role in synthesis;
4. A broader knowledge of organometallic chemistry;
5. A broader understanding of heterocyclic chemistry;
6. A broader understanding of asymmetric synthesis and methods for the resolution of stereoisomers;
7. The ability to undertake a retrosynthetic analysis and to design a synthesis of a target molecule;
8. The ability to read and understand the synthetic organic chemistry literature;
9. The practical ability to perform a routine synthesis in the laboratory;
10. Experience of most common operations in an synthetic chemistry laboratory.

Assessment

mid semester examination: 10%; practical: 20%; practical examination: 10%; final exam: 60%

Prerequisites

VPS2121 Synthetic chemistry I
VPS2122 Synthetic chemistry II

Additional information on this unit is available from the faculty at:

http://www.monash.edu.au/muso/support/