VPS2122 - Synthetic Chemistry II

Leader(s): Dr Bim Graham

Offered

Parkville Second semester 2009 (Day)

Synopsis

This subject aims to provide students with an understanding of:

1. the principles of coordination and bio-inorganic chemistry and how these relate to the design and synthesis of metal-based and metal-chelating therapeutic agents
2. the utility of organometallic reagents in organic synthesis
3. the fundamentals of pericyclic reactions and their application to the synthesis of bioactive compounds
4. the chemistry used to prepare heterocycles and their substituted derivatives, including several important heterocyclic drugs.

Objectives

After completing this unit students will be expected to be able to:

1. Describe and rationalise the properties of simple coordination complexes;
2. Describe synthetic routes for preparing coordination complexes;
3. Explain how a variety of metal-based therapeutic agents work;
4. Draw mechanisms and rationalise the outcome of a range of organometallic, pericyclic and heterocyclic reactions;
5. Apply knowledge of organometallic, pericyclic and heterocyclic reactions to the design of synthetic routes for preparing simple organic compounds;
6. Describe the syntheses of several important heterocyclic drugs;
7. Demonstrate the development of synthetic laboratory skills appropriate for a 2nd year student;
8. Demonstrate the development of written communications skills appropriate for a 2nd year student.

Assessment

practical exam 10%; practical reports 20%; final examination (2.5 hours) 70%

Contact hours

24 1 hour lectures, twelve 1 hour whole class tutorials, nine 4 hour practical classes (total of 72 hours)

Prerequisites

PSC1021 (or VPS1021) Organic chemistry I
PSC1022 (or VPS1022) Organic chemistry II

Additional information on this unit is available from the faculty at:

http://www.monash.edu.au/muso/support/students/browserset.html