BMC2022

Synthetic Chemistry B ( 6 points, SCA Band 2, 0.125 EFTSL)

Leader: Dr Bernard Flynn

Offered:
Parkville Second semester 2005 (Day)

Synopsis: Reactive intermediates and mechanisms. Formation and stabilization. Mechanisms of reactions. Chemistry of heterocyclic compounds. Formation of heterocycles. Substitution of heterocycles. Chemistry of bioactive natural products. Retrosynthetic analysis and synthesis. Metal ions in medicine. Bioavailability of metal ions. Electronic and geometric structures.

Objectives: At the completion of this unit, students will: - Understand about how the reactivity associated with key functioinal groups can be utilised to achieve synthetic outcomes. - Be able to name organic molecules according to IUPAC nomenclature. - Understand the reactivity of these functional groups. - Understand basic reaction mechanisms. - Understand basic reaction kinetics and thermodynamics relevant to organic sythesis. - Have the practical ability to perform a basic synthetic step. - Have the practical ability to isolate and purify reaction products. - Understand where and how natural products are available. - Understand metal ions that are available in biological systems. - Understand how nature achieves ligand and cluster synthesis for specialised reactions using metal ions. - Understand spontaneous self-assembly processes for biomolecules.

Assessment: Practical Exam 10%; Practical Reports 20%; Final Examination (2 hours) 70%.

Contact Hours: 36 hours Lectures, 8 Practicals (3-4 hours each)

Prerequisites: CHM1011 Chemistry, CHM1022 Chemistry, BMC1021 Introduction to Medicinal Chemistry, BMC2021 Synthetic Chemistry A

Corequisites: The other core compulsory subjects of the Bachelor of Medicinal Chemistry.