MPH2043

Chemical environment

Dr D Fish

2 hours per week over 14 weeks

Synopsis This subject aims to develop a discerning interpretation of information about chemical substances in order to evaluate their potential and actual effects on humans and animals. Dose-response relationships, exposure standards, Biological Exposure Indices, patterns of organ toxicity, acute and chronic toxicity tests, no observed effect levels, application of in vivo and in vitro test results to humans, sources of information, genotoxicity, reproductive toxicology, neurobehavioural toxicology, immunotoxicology and carcinogenesis will be covered.

Assessment Multiple-choice questions: 50% * 2000-word assignment: 50%

Prescribed texts

Timbrell J A Introduction to toxicology Taylor and Francis, 1989
Amdur M O, Doull J and Klassen C D Casarett and Doull's `Toxicology' 4th edn, Pergamon Press, 1991
Grantham D L Occupational health and hygiene: Guidebook for the WHSO Grantham, 1992