MPH1028

Toxicology I

Professor J McNeil and Dr D Goddard

1 hour 35 minutes per week over 14 weeks plus tutorials * First semester

Synopsis The aim is to foster the discerning interpretation of information about substances in order to assist the evaluation of their adverse effects on humans and animals. At the end of this subject, students will be aware of the principles of toxicokinetics, the more common types of adverse effects of substances and the typical tests used to elicit these effects. In particular, students will be acquainted with mechanisms of toxicity, dose-response relationships, patterns of organ toxicity, acute and chronic toxicity tests, no-observed-effect levels, extrapolation of animal results to humans, genotoxicity, reproductive toxicology, neurobehavioural toxicology, immunotoxicology, measures of risk and risk perception, analytical techniques, and the planning for toxicological emergencies.

Assessment Assignment (2000 words): 50% * Multiple-choice examination: 50%

Prescribed texts

La Dou (ed.) Occupational medicine Appleton and Lange, 1990
Timbrell J A Introduction to toxicology Taylor and Francis, 1989

Recommended texts

Amdur M O and others Casarett and Doull's `Toxicology' 4th edn, Pergamon Press, 1991