Biomedical biochemistry and molecular biology
Dr Wayne Comper
12 points * Four 1-hour lectures, one 6-hour practical and one 1-hour tutorial per week * First semester * Clayton * Prerequisites: BCH2031 and BCH2042 * Prohibition: BCH3011
Objectives On completion of this subject students should understand the molecular biology of gene structure, expression and regulation at a detailed level; comprehend macromolecular structure and function and cell-matrix interactions; achieve a broad view of the importance of biochemistry and molecular biology to current advances in biology, biotechnology, medicine and agriculture; recognise particularly the medical relevance of biochemistry and molecular biology and the application of this discipline to the understanding and treatment of some medical conditions; develop skills in the use of routine biochemistry laboratory equipment and in advanced biochemical and molecular biological techniques; manipulate and interpret biochemical data; develop skills in the communication of scientific information by verbal and written means and by poster displays.
Synopsis This subject is presented in four main themes: (i) molecular biology - gene structure, expression and regulation together with aspects of molecular virology; (ii) macromolecular structure and interaction in relation to biological activity - details of protein structure in relation to evolution, regulation of enzyme activity, the extracellular matrix and dynamic interactions of proteins; (iii) biotechnology - the use of immobilised enzymes, recombinant DNA technology and genetic engineering; (iv) genetic disease - the molecular biology of genetic disease and gene therapy. Practical training extends the student's skills in modern and advanced techniques in biochemistry and molecular biology.
Assessment Examinations (2x2 hours): 80% * Laboratory: 20%
Prescribed texts
Alberts B and others Molecular biology of the cell 3rd edn, Garland, 1994
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