Molecular biology of the cell
Dr Wayne Comper
12 points * Four 1-hour lectures, one 6-hour practical and one 1-hour tutorial per week * Second semester * Clayton * Prerequisites: BCH3011 * Prohibition: BCH3042
Objectives On the completion of this subject students should understand cell biology and gene expression; comprehend macromolecular structure and function and cell-matrix interactions; understand intracellular signalling at the molecular level; comprehend organelle formation and function; achieve a broad view of the importance of biochemistry and molecular biology to current advances in biology and medicine; develop skills in the use of routine biochemistry laboratory equipment and in advanced biochemical and molecular biological techniques; manipulate and interpret biochemical data; find information in the scientific literature on particular topics in biochemistry and molecular biology; prepare a substantial written work on a topic in biochemistry and molecular biology; develop skills in the communication of scientific information by verbal and written means and by poster displays.
Synopsis This subject is presented as five main themes based on cellular and molecular biology: (i) plasma membrane and cytoskeleton - structure and function of the plasma membrane, control of cell shape, cell movement and cell-cell interaction; (ii) biophysics of the cell and its environment - the extracellular matrix, membrane transport, diffusion and osmosis; (iii) signal transduction, cell regulation, development and differentiation - hormones and receptors, second messenger systems, the immune system, apoptosis, regulation of cell growth and the cell cycle; (iv) synthesis and intracellular trafficking of proteins and glycoproteins - post translational processing of secretory and membrane proteins, the biochemistry of lysosomes; (v) formation and function of chloroplasts and mitochondria - cellular bioenergetics, evolution and role in disease and ageing. Practical training extends the student's skill in modern and advanced techniques in biochemistry and molecular biology.
Assessment Essay: 25% * Examinations (2 x 2 hours): 60% * Laboratory: 15%
Prescribed texts
Alberts B and others Molecular biology of the cell 3rd edn, Garland, 1994
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