Genetic principles II - fundamentals of genetic engineering
Associate Professor Stephen McKechnie
8 points * Four 1-hour lectures and one 5-hour combined tutorial/laboratory session per week * Second semester * Clayton * Prerequisites: GEN2011
Objectives On the completion of this subject students should understand the basic concepts in methods that underlie genetic engineering. They should be familiar with the basic concepts of microbial genetics; understand the molecular structure of genes, the diversity of mechanisms for control of gene expression, and the techniques necessary to study these mechanisms. Students should appreciate the essential genetic features of eukyarotes; understand the unique features of the genetics of plants and animals, including humans, and be able to manipulate and analyse DNA sequences using computers and international genetic data bases. Students should have become aware of the genetic basis for several important inherited disorders and diseases in humans; have developed further skills in data collection, data analysis and data organisation necessary in the preparation and presentation of scientific reports; have developed further problem-solving skills, including the use of simple statistical concepts for data analysis and interpretation; have developed further an awareness of the application of genetics for the benefit of society; have learnt basic laboratory techniques and appreciate the principles underlying experimental design.
Synopsis GEN2022 assumes a knowledge of genetic principles covered in GEN2011 and provides foundations in microbial and molecular genetics that are essential to genetic engineering. The molecular basis for gene transcription and translation to form macromolecules are part of these foundations. The structure and organisation of genomes and expression of genes from higher eukaryotes, mainly humans, plants and animals, is also a major component of the subject. Practical classes and problem sessions are designed to complement the lecture material.
Assessment Examinations (3 hours): 70% * Practical work: 25% * Assignments: 5%
Prescribed texts
Hartl D L Genetics 3rd edn, Jones and Bartlett, 1994
Nickerson R P Genetics: A guide to basic concepts and problem solving Harper-Collins, 1990
Recommended texts
Lodish H and others Molecular cell biology 3rd edn, Freeman, 1995
Fosket D E Plant growth and development: A molecular approach Academic Press, 1994
Griffiths A J F and others An introduction to genetic analysis 5th edn, Freeman, 1993
Maloy S R and others Microbial genetics 2nd edn, Jones and Bartlett, 1994
Old R W and Primrose S B Principles of gene manipulation 5th edn, Blackwell, 1994
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