Genetic principles I - from chromosomes to populations
Associate Professor Stephen McKechnie
8 points * Four 1-hour lectures and one 5-hour combined tutorial/laboratory session per week * First semester * Clayton * Prerequisites: BIO1011 and either BIO1022 or BIO1032 or BIO1042, VCE Chemistry and CHM1011 and CHM1022 are strongly recommended
Objectives On the completion of this subject students will understand the basic principles of inheritance in various organisms, particularly the application of Mendel's laws; have encountered the range of diverse organisms used in studying genetics and understand their common and unique features for the purpose of studying genetics (organisms include viruses, bacteria, fungi, plants, invertebrates and vertebrates, including humans); be able to describe the common features of the chromosomal and molecular mechanisms that underlie inheritance; understand the basic structure of DNA and genes and chromosomes; understand basic concepts of quantitative and population genetics; have developed skills in data collection, data analysis and data organisation necessary in the preparation and presentation of scientific reports; have developed problem solving skills, including the use of simple statistical concepts for data analysis and interpretation; have developed an awareness of the value of genetics to human society; have mastered basic laboratory techniques and appreciate the principles underlying experimental design.
Synopsis GEN2011 covers the basic principles of genetics and introduces many of the concepts, techniques and organisms fundamental to the discipline. The subject includes the structure and organisation of DNA and of chromosomes, cell division, Mendelism, mutation, chromosome variations (especially in humans), gene mapping, cytoplasmic inheritance, basic gene expression and its regulation, basic microbial genetics and principles of population and quantitative genetics. Practicals are designed to complement and illustrate the current lectures.
Assessment Examinations (3 hours): 70% * Practical work: 25% * Assignments: 5%
Prescribed texts
Hartl D L Genetics 3rd edn, Jones and Bartlett, 1994
Nickerson R P Genetics: A guide to basic concepts and problem solving Harper Collins, 1990
Recommended texts
Conner J M and Ferguson-Smith M A Essential medical genetics 4th edn, Blackwell, 1993
Griffiths A J F and others An introduction to genetic analysis 5th edn, Freeman, 1993
Maloy S R and others Microbial genetics 2nd edn, Jones and Bartlett, 1994
Russell P J Genetics 4th edn, Harper Collins, 1996
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