This unit entry is for students who completed this unit in 2016 only. For students planning to study the unit, please refer to the unit indexes in the the current edition of the Handbook. If you have any queries contact the managing faculty for your course or area of study.

PSC1032 - Physical chemistry II

6 points, SCA Band 2, 0.125 EFTSL

Undergraduate - Unit

Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.

Faculty

Pharmacy and Pharmaceutical Sciences

Coordinator(s)

Dr Charlie Dong

Offered

Parkville

Second semester 2016 (Day)

Notes

Previously coded PSC1072

Synopsis

Solutions, self-assembled systems, multiphase liquid systems and the properties of solids that yield pharmaceutical solutions are key to the performance and manufacture of pharmaceutical products. This unit aims to build on PSC1031 Physical Chemistry I to provide students with a firm understanding of the physical chemistry that underpins the properties and dissolution of pharmaceutical solids and additives to form solutions. In particular an understanding of the physicochemical properties of pharmaceutical solids (drugs and excipients), their transfer into solution form and properties of those solutions from a pharmaceutical science perspective will set the foundation for students to understand the impact of these properties and concepts in pharmaceutical and other formulated products. The key concepts are related directly to aspects of a suite of representative pharmaceutical products allowing the students to put the concepts into a relevant context. The understanding of these principles will also assist students in their understanding in some areas of chemistry, physiology and biology.

This will involve:

physical chemistry of solutions
solids, semisolids and solubility
interfacially active molecules and their use in formulation
acid-base functional groups

Outcomes

At the end of this unit students will be expected to:

Analyse the physicochemical principles that underpin the important processes of pharmaceutical solids dissolving to form a solution. Describe, predict and calculate dissolution, solubility and distribution;
Predict and calculate the influence of functional groups and structure on solution behaviour, including colligative properties and conductivity;
Explain and predict the behaviour of surface-active agents at interfaces and in solution, and explain how micelles can improve drug solubilization;
Describe the physicochemical principles behind the formulation of liquid products, including one and two phase liquid systems, prepare and evaluate basic liquid formulations for pharmaceutical applications.
Describe and analyse the properties of pharmaceutical solids and semisolids, such as crystallinity, melting point, and predict their impact on solubility, stability and bioavailability;
Describe rheological concepts and discriminate between different rheological properties for fluids;
Define the role and effect of components (excipients) used to produce solution based dose forms in the pharmacy field and evaluate individual excipients, based on their physicochemical properties, in the context of the pharmaceutical product or formulation;
Measure fundamental solution properties through practical exercises and relate experimental results to theoretical concepts in the unit and from PSC1031.

Assessment

Final exam (3 hour) 50%; active learning (in-class and online) 10%; tutorial, practical and workshops 10%; in-semester tests 10%; practical test 5%; group written assignment 15%.