Undergraduate - UnitPAC3241 - Drug delivery, disposition and dynamics

This unit entry is for students who completed this unit in 2013 only. For students planning to study the unit, please refer to the unit indexes in the the current edition of the Handbook. If you have any queries contact the managing faculty for your course or area of study.

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6 points, SCA Band 2, 0.125 EFTSL

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Level	Undergraduate
Faculty	Faculty of Pharmacy and Pharmaceutical Sciences
Offered	Sunway First semester 2013 (Day) Parkville First semester 2013 (Day)
Coordinator(s)	Suzanne Caliph (Parkville); Dr Saravanan Muniyandy (Sunway)

Synopsis

The overall aim of this unit is to introduce 3rd year pharmacy students to the key concepts associated with clinical pharmacokinetics, drug metabolism and disposition, and therapeutic drug monitoring and how these may impact on patient therapeutic dosage regimens in various disease states, conditions and with concomitant medication. Additionally, students will build upon their knowledge on surface properties and formulation of heterogenous systems, including dispersions, semi-solids, suppositories, pessaries, aerosols and modified release products.

This will involve the study of:

effect of metabolism, drug transporters and disease on pharmacokinetics
drug interactions
management of poisons
therapeutic drug monitoring
solid in liquid dispersions
aerosols and foams
semi-solids, suppositories and pessaries
modified release formulations

Outcomes

At the end of this unit students will be able to:

Describe steady state plasma concentration and factors affecting steady state plasma concentration; calculate steady state concentrations after a particular dose and dosing interval;
Describe common routes of drug metabolism and drug transport and predict changes in pharmacokinetics associated with inter-individual variability;
Explain how drug transporters present in the small intestine, liver, kidney and blood-brain barrier may impact on disposition of drugs and potential drug-drug interactions;
Evaluate and predict how pharmacokinetics may alter in various disease states and patient groups (pregnancy, obesity, geriatrics, paediatrics);
Generate a drug regimen based on therapeutic drug monitoring principles;
Discuss particular examples where drug-drug interactions impact on pharmacokinetics and patient therapy;
Explain and exemplify formulation principles of colloidal and solid in liquid dispersions, aerosol systems and foams, semisolids and modified release pharmaceutical drug delivery systems.

Assessment

Final exam (3 hour): 70%; in-semester assessments: 30%.

Chief examiner(s)

Suzanne Caliph

Contact hours

Contact hours for on-campus students:
Thirty three 1-hour lectures
Four 3-hour workshops
One 3 hours online practical

Prerequisites

PAC2232 Drug delivery and disposition

Additional information on this unit is available from the faculty at:

http://www.monash.edu/pharm/current/