VCP2032

Pharmaceutics I B ( 3 points, SCA Band 2, 0.063 EFTSL)

Undergraduate

(PHA)

Leader: Ms. Suzanne Caliph

Offered:
Parkville Second semester 2005 (Day)

Synopsis: Pharmacokinetics of intravenous and oral administrations. One compartment pharmacokinetics. Two compartment pharmacokinetics. Hepatic clearance. Renal clearance. Non-compartmental methods. Biopharmaceutics. Structure and properties of membranes. Mechanisms of drug transfer across membranes. Effect of ionisation. pH partition hypothesis. Pre-systemic clearance. Bioavailability. Bioequivalence. Dosage form performance tests. In Vitro, In-vivo correlations.

Objectives: Students will develop an understanding of: principles outlined in the syllabus in relation to oral drug delivery, biopharmaceutics and pharmacokinetics of intravenous and oral drug administrations; theoretical and practical issues of assessment of drug bioavailability and bioequivalence, the design of bioavailability and bioequivalence studies both in terms of regulatory requirements and also in terms of their ability to critically evaluate literature-based information sources. various factors affecting bioavailability including dose form issues, regional absorption, metabolic events and how these issues can be addressed during bioavailability/bioequivalence testing.

Assessment: At the end of the semester, a written examination will be held to examine the learning materials from lectures and problem based learning workshops. The examination will be designed to assess whether the general teaching objectives and individual learning outcomes of each topic covered in this unit have been met. The written examination will be worth 100% in total and students must score a minimum of 50% to pass the unit.

Contact Hours: 34 hours of lectures, 5 Workshops of 3 hour duration and 1 tutorials of 1 hour duration. It is expected that this unit will require participants to allocate and average of 6 hours per week for 12 weeks (a total of 78 hours per study period to successfully complete this unit.

Prerequisites: All 1st Year B. Pharmacy units.

Corequisites: There are no special corequisites for this unit