RTS4020

Radiobiology and dosimetry ( 6 points, SCA Band 2, 0.125 EFTSL)

Leader: Dr Ray Budd

Offered:
Clayton SA-02 2005 (OCL)
Clayton Summer 2005 (OCL)

Synopsis: Introduction to biological effects of ionizing radiation on cells & tissues and mechanisms repairing sustained biological damage, study of systemic and total body responses to early/late effects of radiation, hereditary effects and effects on the embryo & foetus. Detailed study of principles of radiation protection and possible risks associated with irradiation during diagnostic and therapeutic application from a risk vs benefit perspective. Estimates of risk assessment are evaluated using accepted theories of dose vs response. Finally, study of application and techniques of various radiation therapy treatment schedules that maximise tumour response and minimise effects on normal tissues.

Objectives: On successful completion of this unit students will be able to: 1. understand the known biological effects of radiation on cells and tissues; 2. describe the difference in effectiveness of various types of ionising radiation; 3. recognise and explain the mechanisms of cellular repair radiation damage; 4. explain the difference between early and late effects of radiation damage; 5. calculate radiation dose in a variety of diagnostic and therapeutic scenarios; 6. discuss the current scientific theories relating to the risk associated with dose; 7. understand the rationale used to determine the most appropriate radiation treatment schedules; and 8. understand the modifying techniques used to obtain the maximum gain from a particular treatment schedule.

Assessment: Written examination (three hours): 60% + Two assignments: 40%

Prerequisites: RTS4000, RTS4010, RTS4021

Corequisites: RTS4012, RTS4022