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VCP2021

Medicinal chemistry IIA (6 points)

(PHA)

Leader: Dr Martin Scanlon

Offered:
Parkville First semester 2005 (Day)

Synopsis:

Objectives: Students will develop an: - Understanding of the nomenclature and meaning of terms used to describe the three-dimensional structures (stereochemistry) of drug molecules; spectroscopic methods used in the analysis and structural determination of drugs; the theory and application of thermodynamics; the structural and mechanistic bases for the action of the autonomic neurotransmitters and related agents; factors affecting the physiochemical properties and reactivity of drugs based on aromatic frameworks; factors influencing the three dimensional structures of proteins; the partition of substances between various phases as applied to both the analyses of drugs and their transport in the body; principles of electrochemistry applied in the analysis of drugs; the chemical principles underlying selected diagnostic aids relevant to pharmacy; the application of radioisotopes in pharmacy. - Ability in the areas of measurement and recording of data relevant to the understanding of drug structure and reactivity; numerical calculations based on experimental or theoretical data; report writing or oral presentations based on the results of experimental work. - Appreciation of the general chemical principles of enzymatic catalysis; the importance of chemical reactions in determining drug transport and metabolism; the application of the principles of medicinal chemistry to the search for selectivity in therapeutic agents.

Assessment:

Contact Hours: 64 hours of Lectures, 9 hours of Tutorials and 6 hours Practicals.


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