CHM3942

Synthesis of bioactive compounds

(SCI)

Dr Peter Junk

6 points + Two 1-hour lectures, one 1-hour tutorial and the equivalent of 3 hours of laboratory activity per week + Second Semester + Clayton + Prerequisites: 12 points of level 1 chemistry and normally 12 points of level 2 chemistry, or permission + Prohibitions: permission if completed CHM3031, CHM3042, CHM3051 or CHM3062

Synopsis: This subject is approached first by an introduction to the discovery, isolation and identification of naturally occurring bioactive molecules. This is followed by a discussion of the theoretical basis of the design of synthetic pathways for target bioactive molecules. Selected practical examples are then treated using the principles learned. This then leads on to a description of the application of modern organometallic reagents in sythesis. Finally the synthesis, structure and reactivity of bioinorganic compounds, many of which have been designed to mimic Nature's armoury of molecules and catalysts, are examined.

Assessment: One 2-hour examination: 50% + Assignments and computer testing: 20% + Laboratory work and short laboratory reports and proforma reports: 30%