Affiliated institutes
Below are listed the interests and opportunities for research available at
affiliated institutes/centres, which have connections with the Faculty of
Medicine.
Although students may undertake their research at an affiliated
institute/centre, they can only be enrolled at Monash University through a
department or an accredited academic unit of the Faculty. Such students will be
required to meet all the requirements and obligations of the designated
department. In addition, all aspects of their candidature and scholarships will
comply with Monash University regulations.
Director:
Professor J W Funder
Location: Commercial Road, Prahran
Postal address: PO Box 6492, Melbourne 8008
Telephone: (03) 9522 4333
Fax: (03) 9521 1362
Email: j.funder@med.monash.edu.au
- Alfred and Baker Medical Unit Therapy of hypertension and
atherosclerosis; exercise in cardiovascular disease; heart failure
pathophysiology and treatment; human vascular biology; cardiovascular responses
to stress; new methods of cardiovascular risk assessment and reduction;
clinical pharmacology of new cardiovascular drugs.
- Cardiac Surgical Research Unit Biology of ageing - relevance to
cardiac surgery; enhancing myocardial metabolism; clinical projects with
cardiac surgery and transplant units.
- Cardiovascular Nutrition Laboratory Clinical and laboratory
nutrition; studies linked to effects of diets on cardiovascular physiology and
metabolism.
- Cell Biology Laboratory Vascular effects of TGF[beta] and the
FGFs and molecular mechanisms; blood vessel development, growth remodelling and
vascular hypertrophy in hypertension; novel vascular therapies; molecular cell
biology of human atherosclerotic lesions.
- Cell Biology - Diabetes Laboratory Mechanisms by which diabetic
stimuli signal pathological responses in blood vessels and cultured cells; ion
transport mechanisms in vascular cells; role of Na+/H+
exchanger in vascular cell growth; cell stress as a stimulus for growth factor/
hormone release and cell proliferation.
- Cell Biology - Morphology Laboratory Regulation of vascular
smooth muscle growth in hypertension and injury; transcription factor
activation in resistance vessels; cardiac fibrosis.
- Cellular Biochemistry Laboratory Phosphatidylinositol (PI)
turnover in the heart in health and disease, especially changes occurring under
conditions of myocardial ischemia and reperfusion.
- Experimental Cardiology Laboratory Mechanisms of noradrenaline
release during acute cardiac ischaemia; local modulation of neurotransmitter
release during cardiac failure; role of PI turnover in ischaemic arrhythmias -
new therapeutic strategies. Cardiac transgenic models in arrhythmias and
cardiac failure.
- Hormones and the Vasculature Laboratory Effects of male and
female sex hormones on the cardiovascular system and vasculature;
cardiovascular implications of menopause; cardiovascular changes during the
menstrual cycle; cardiovascular actions of phytohormones.
- Human Neurotransmitter Laboratory Human stress responses,
neurobiology of panic disorder, radiotracer studies of sympathetic nervous
system function; human brain neurotranmitters; thermogenesis and obesity; high
blood pressure; heart failure.
- Lipoprotein and Atherosclerosis HDL receptor and protection
against premature heart disease; interaction between HDL, cell receptors,
signalling events and cholesterol mobilisation.
- Molecular Endocrinology Laboratory Molecular biology of ATII
receptors, structure/function relationships, mechanism of internalisation,
receptor phosphorylation and of aldosterone and cortisol; screening for
variation in genes that regulate blood pressure in hypertension syndromes.
- Molecular Genetics Laboratory Investigation of genetic
determinants in human hypertension. Pathophysiology of glucocorticoid action in
glucocorticoid and mineralocorticoid receptor knockout mice; production of an
11[beta]HSD2 knockout mouse.
- Molecular Hypertension Laboratory 11[beta] cortisol metabolism by
hydroxysteroid dehydrogenase (HSD) isoforms in disease; tissue-specific
regulation of 11[beta]HSD gene expression; structural analysis of the
11[beta]HSD2 gene; analysis of 11[beta]HSD gene in hypertension; expression
cloning of new 11[beta]HSD enzymes.
- Molecular Neurocardiology Laboratory Regulation of neurotrophin
synthesis in the heart and control of their receptors; mechanisms for acutely
and chronically regulating noradrenaline transport; analysis of the
noradrenaline transporter gene in human hypertension; in vivo and in
vitro studies in animal models of heart failure.
- Molecular Physiology Laboratory Steroid receptors; aldosterone
action; cardiac fibrosis, salt and aldosterone; neurobiology of
mineralocorticoid receptors in the CNS; pseudohypoaldosteronism.
- Molecular Signalling Laboratory Structure-function studies of the
GTP-binding protein dynamin in membrane trafficking; molecular regulation of
telomerase activity in cancer; stress-sensitive protein kinases in heart and
neoplastic cells.
- Neuropharmacology Laboratory CNS monoamine neurotransmitters
noradrenaline, serotonin and dopamine; CNS renin-angiotensin system and
endothelin in cardiovascular regulation; central anti-hypertensive drugs;
hypertension-induced changes in circulatory control.
- Peptide Biology Laboratory Peptides in the cardiovascular and
neuroendocrine axis; peptidases involved in peptide hormone biosynthesis and
metabolism; design of peptidase inhibitors and their use as potential
therapeutic agents; peptide and protein purification and characterisation.
- Vascular Biology Laboratory vWF structure and function; roles of
the cell adhesion molecule GMP-140 the neutrophil inflammatory responses and
haematopoiesis; roles of the membrane glycoprotein PECAM-1 in cell adhesion and
function; in vitro and in vivo models of thrombosis, inflammation
and angiogenesis.
Director:
Professor J Mills
Location: Yarra Bend Road, Fairfield
Postal address: PO Box 254, Fairfield 3078
Telephone: (03) 9282 2123
Fax: (03) 9282 2126
Email: j.mills@med.monash.edu.au
- Hepatitis A virus Studies of virus replication strategies.
- Hepatitis B virus Mechanisms of replication control; pathogenesis
and treatment of hepatitis B in ducks.
- Hepatitis E virus Development of new diagnostic tests and
vaccines.
- HIV Numerous projects, including control of transcription by
cellular factors, mRNA splicing mechanisms and significance, mechanism of cell
killing, replication strategies in stationary cells (including T-cells and
monocyte-macrophages), mechanism of action of ancillary proteins (Nef, Vif,
Vpr, Rev, Tat), immune response to HIV infection, control of reverse
transcription, transcription and translation in monocyte-macrophages, studies
on assembly and maturation of HIV, biology of HIV infection of macrophages,
signal transduction during HIV infection of macrophages and lymphocytes,
interactions between other viruses and HIV, development of attenuated variants
of HIV, biology of HIV and SIV in macaques, HIV vaccine development.
- Respiratory syncytial virus Studies of the cell receptor for
human and animal RSVs, and structural, functional and chemical studies of the
attachment protein (G protein) and the matrix proteins (M, M2) RSV.
- Rubella virus Morphogenesis and replication strategies of rubella
virus; mechanism of mitochondrial injury by rubella virus.
Director:
Professor D Copolov
Location: 155 Oak Street, Parkville
Postal address: Locked Bag 11, Parkville 3052
Telephone: (03) 9388 1633
Fax: (03) 9387 5061
Research at the institute focuses on schizophrenia and Alzheimer's disease.
- Alzheimer's Disease Research Group The role of amyloid precursor
protein in Alzheimer's disease; the role of metal ions (specifically zinc) in
dementia.
- Biostatistics and Psychometrics Latent trait and class modelling
of psychiatric symptoms and disorders; development and assessment of
psychological tests; covariance structure analysis; computationally intensive
statistics.
- Brain Dynamics The use of multi-channel EEG measures in detecting
functional abnormalities in schizophrenia; Computer simulation of cortical
activity.
- Cell Biology Neuronal development, neurotransmitters and
schizophrenia.
- Cognitive Neuropsychiatry Neuropsychological deficits in
schizophrenia; structural and functional imaging studies; the association of
olfactory deficits with psychotic symptoms. The neuropsychological,
neuroimaging and audiological investigation of auditory hallucinations.
- Genetics Twin and family studies; children of psychotic parents.
- Neurochemistry Pharmacological, biochemical and molecular studies
aimed at identifying changes in brain tissue and blood from schizophrenic
subjects; studies of neurochemical changes that occur in response to
neuroleptic drug treatment.
- Neurophysiology and Neurovisual Research Neurophysiological
investigations of ocular motor and attentional function in Alzheimer's disease,
the AIDS dementia complex and schizophrenia; brain mapping of ocular motor and
attentional functions using evoked potentials and PET.
- Policy and Analysis Psychiatric epidemiological studies using the
Victorian Psychiatric Case Register; mental health services research and
evaluation; classification and funding design of mental health services.
- Psychopharmacology and Clinical Neuroendocrinology Evaluation of
new antipsychotic drugs; the role of sex hormones in patients with psychoses;
studies of psychopathology related to post-mortem brain chemistry.
Director:
Professor H G Burger
Location: Level 4, Block E, Monash Medical Centre, 246 Clayton Road, Clayton
Postal address: PO Box 5152, Clayton 3168
Telephone: (03) 9550 4372
Fax: (03) 9550 6125
Email: henry.burger@med.monash.edu.au
- Molecular Endocrinology Laboratory Steroid hormone action
including resistance syndromes; intestinal biology including studies on the
molecular basis of intestinal adaptation; molecular oncology.
- Uterine Biology Laboratory Studies on the biology of the uterus,
particularly tissue remodelling, menstruation and implantation; studies of the
molecular endocrinology of pregnancy and parturition; studies of endometrial
cancer.
- Male Reproduction Laboratory Studies on the hormonal control of
spermatogenesis; studies on the reproductive endocrinology of the male. Studies
on the biology of inhibin.
- Female Reproduction Laboratory Studies on reproductive
endocrinology in the female; endocrinology of ovarian cancer; studies of female
infertility; menopause; osteoporosis, hormone replacement therapy; studies of
ovarian follicular development and atresia. Studies on the biology of inhibin.
- Breast Cancer Laboratory, Victorian Breast Cancer Research Consortium
Inc. Studies of the role of oestrogens in breast cancer; endocrine control
of adipose tissue.
- Pharmacology Laboratory The autonomic nervous system in
cardiovascular control; signal transduction processes in cardiac and vascular
smooth muscle, receptors involved in modulation of transmitter release in the
central nervous system; hormonal regulation of the cardiovascular system.
- Neuroendocrine Laboratory Neuroendocrinology and endocrinology
including studies relevant to nutrition, reproduction, growth, lactation,
control of body weight, cancer and stress. Work is carried out using
sophisticated in vivo and in vitro models and molecular and
single cell techniques.
wwwdev@monash.edu.au
Tue Oct 6 02:34:14 EST 1998