Pathology and Immunology
Head: Professor B-H Toh
Address: Department of Pathology and Immunology, Alfred Hospital, Commercial
Road, Prahran 3181
Telephone: (03) 9276 2713
Fax:(03) 9529 6484
Email: ban-hock.toh@med.monash.edu.au
- Autoimmunity Molecular and cellular basis of systemic and
organ-specific autoimmune diseases; Identification and molecular cloning of
target autoantigens; Delineation of the role of T lymphocytes in the
immunopathogenesis of autoimmune gastritis; Role of adhesion molecules;
Mechanisms of tolerance to extrathymic gastric autoantigens.
- Allergy Role of T cells and T cell clones to defined grass
allergens in the genesis of allergic responses; Role of T cells in airway
inflammation.
- Thymus biology Role of the thymic stroma in the intrathymic
development of T lymphocytes; Generation, identification and functional
characterisation of monoclonal antibodies to the thymic stroma.
- Antigen presentation Role of MHC molecules in antigen
presentation and immunological tolerance; Structure and function of T cell
receptors; Fine specificity of T cell receptors.
- NK cells Role of NK cells in health and disease.
- Exocytosis Molecular biology of the Golgi complex: identification
and cloning of Golgi autoantigens; Identification and definition of the
molecular signals which retain proteins in the Golgi.
- Endocytosis Molecular biology of the endocytic pathway; Molecular
cloning of proteins associated with endosomes; Structure and function of
endosomal proteins.
- Cell division Structure and function of proteins associated with
cell division.
- Plasma membrane proteins Structure-function studies of surface
membrane proteins on plasma cells and of the transferrin receptor.
- Obesity Molecular analyses of the obesity gene.
- Developmental molecular biology Regulation of gene expression of
a defined gastric mucosal gene; The gastric proton pump; Molecular basis of
acid secretion and the role of the cytoskeleton.
wwwdev@monash.edu.au
Tue Oct 6 02:34:14 EST 1998