MED1011

Principles of biochemistry

Dr M-P Van Damme (Biochemistry and Molecular Biology)

Objectives The aim of this subject is to provide students with an introduction to three fundamental topics of contemporary biochemistry. This will allow students to achieve a basic knowledge for the units to be taught later in the medical curriculum. The objectives of the lecture course are for students to understand the structure and properties of molecules associated with the life process; to comprehend the physical and biochemical properties of proteins, especially enzymes; and to understand aspects of cellular metabolism in terms of release of energy and dietary inputs. The objectives of the practical/small-group teaching course are to allow students to extend and complement material given in the lectures as well as to provide experience in manual skills and problem solving.

Synopsis The nature of biological molecules and importance of water in cellular biology. The primary, secondary, tertiary and quaternary structures of proteins and how these determine biological function. Enzyme-catalysed reactions, kinetic analysis of enzyme activity, enzyme inhibition and regulation. Biophysical principles involved in metabolic pathways, importance of ATP in cellular metabolism. The generation of ATP from acetyl CoA via electron transport chain and tricarboxylic acid cycle and the nature and role of carbohydrates and lipids in energy metabolism of the cell.

Assessment End-of-semester examination (2 hrs): 90% · Small group teaching/practical class: 10%

Recommended texts

McKee T and McKee J R Biochemistry: An introduction Brown, 1996
Lehninger A L and others Principles of biochemistry 2nd edn, Worth, 1993
Marks D B, Marks A D and Smith C M Basic medical biochemistry Williams and Wilkins, 1996

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