Head: Professor B-H Toh
Address: Department of Pathology and Immunology, Alfred Hospital, Commercial
Road, Prahran 3181
Telephone: (03) 9276 2713
Molecular basis of systemic and organ-specific autoimmune diseases,
identification and molecular cloning of target autoantigens, delineation of the
role of T lymphocytes in the immunopathogenesis of autoimmune gastritis and
mechanisms of tolerance to extrathymic gastric autoantigens; structure-function
studies of surface membrane proteins on plasma cells; molecular analyses of the
obesity gene; allergy; generation of T cell clones to defined grass allergens
and study of the role of T cells in the genesis of allergic responses; asthma:
role of T cells in airway inflammation (in collaboration with Professor E H
Walters, Department of Medicine); developmental molecular biology: regulation
of gene expression of a defined gastric mucosal gene, the gastric proton pump;
molecular biology of the Golgi complex: identification and cloning of Golgi
autoantigens; identification and definition of the molecular signals which
retain proteins in the Golgi complex; molecular biology of endocytosis;
identification, cloning and functional analyses of proteins associated with
early endosomes; molecular biology of cell division; identification, cloning
and functional analysis of proteins regulating cell division; cytokines: role
in human diseases; thymus biology: the role of the thymic stroma in the
intrathymic development of T lymphocytes; generation, identification, and
functional characterisation of monoclonal antibodies to the thymic stroma; the
role of MHC molecules in antigen presentation and immunological tolerance;
structure and function of T cell receptors; fine specificity of T cell receptors.