Molecular, developmental and applied genetics
Dr David Smyth
12 points * 10 hours per week * First semester * Clayton * Prerequisites: GEN2022
Objectives On the completion of this subject students will have an overview of the nature of the genomes of prokaryotes and eukaryotes; appreciate specialised aspects of the molecular biology of bacteria; be familiar with modern methods of DNA and gene manipulations; be able to review recent findings on gene structure and function during development; be aware of applications of genetics in medical, agricultural and industrial biotechnology; have developed skills in the presentation of data and scientific ideas verbally, in writing, and where possible, through the use of computer assisted learning.
Synopsis This subject is focused on recent advances in molecular genetics and genetic engineering. Topics covered include genome architecture of prokaryotes and eukaryotes, the molecular biology of bacteria, methods of DNA and gene manipulation and the analysis of gene structure and function during development. The applications of genetics in medical, agricultural and industrial biotechnology are emphasised. Practicals are designed to complement lecture material and will provide students with experience in recombinant DNA techniques, DNA sequencing and methods for studying gene expression after introduction of foreign genetic material into the genomes of higher eukaryotes.
Assessment Written (2500 words): 15% * Examinations (3 hours): 50% * Practical work: 35%
Prescribed texts
Old R W and Primrose S B Principles of gene manipulation 5th edn, Blackwell, 1994
Recommended texts
Alberts B and others Molecular biology of the cell 3rd edn, Garland, 1994
Fincham J R S Genetic analysis Blackwell, 1994
Fosket D E Plant growth and development: A molecular approach Academic Press, 1994
Kung S and Wu R Transgenic plants vol. 1, Engineering and utilisation Academic Press, 1993
Latchman D Gene regulation 2nd edn, Chapman and Hall, 1995
Lodish H and others Molecular cell biology Scientific American, 1995
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