Pathology and Immunology

Head: Professor B H Toh

Address: Department of Pathology and Immunology, Alfred Hospital, Commercial Road, Prahran, 3181

Phone: (03) 9276 2713

Molecular basis of systemic and organ-specific autoimmune diseases, identification and molecular cloning of target autoantigens, delineation of the role of T lymphocytes in the immunopathogenesis of autoimmune gastritis and mechanisms of tolerance to extrathymic gastric autoantigens; structure-function studies of surface membrane proteins on plasma cells; molecular analyses of the obesity gene; allergy; generation of T cell clones to defined grass allergens and study of the role of T cells in the genesis of allergic responses; asthma: role of T cells in airway inflammation (in collaboration with Professor E H Walters, Department of Medicine); developmental molecular biology: regulation of gene expression of a defined gastric mucosal gene, the gastric proton pump; molecular biology of the Golgi complex: identification and cloning of Golgi autoantigens; identification and definition of the molecular signals which retain proteins in the Golgi complex; molecular biology of endocytosis; identification, cloning and functional analyses of proteins associated with early endosomes; molecular biology of cell division; identification, cloning and functional analysis of proteins regulating cell division; cytokines: role in human diseases; thymus biology: the role of the thymic stroma in the intrathymic development of T lymphocytes; generation, identification, and functional characterisation of monoclonal antibodies to the thymic stroma; the role of MHC molecules in antigen presentation and immunological tolerance; structure and function of T cell receptors; fine specificity of T cell receptors.

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