Medicine
Head: Professor N M Thomson
Address: Department of Medicine, Monash Medical School, Alfred Hospital,
Prahran, 3181
Phone: (03) 9276 2640
- Cardiovascular Growth factors; hyperplasia and hypertrophy in
hypertension and re-stenosis after balloon angioplasty; sodium-hydrogen
exchange; noradrenaline release in myocardial ischaemia; mechanisms of the
effects of physical training in experimental hypertension; effects of
lipoproteins on vascular reactivity; heart failure; cardiac and vascular
hypertrophy in hypertension; novel risk factors; risk markers for coronary
disease; sympathetic activity in hypertension; heart failure; autonomic
activity and sudden death; non-pharmacological treatment of hypertension;
cardiovascular effect of exercise; endothelial dysfunction in hyperlipidaemia
and hypertension; mechanisms of obesity and obesity-related hypertension;
molecular biology of failing human heart.
- Nephrology Mechanisms of chronic renal injury in
glomerulonephritis with emphasis on the role of growth factors (experimental
animal and human studies); growth factors in experimental and human allograft
rejection (kidney, heart, pancreas and gout); 11-.-hydroxysteriod dehydrogenase
in hypertension associated with renal disease; renal disease in cardiac
transplant recipients; peritoneal dialysis.
- Medical oncology Clinical trials and programs involving the study
of prognostic factors and systemic therapy in various malignancies, including
solid tumours and lymphomas; phase II and III collaborative studies of systemic
therapy alone or as part of a combined modality treatment program in various
malignancies; the role of supportive psychological counselling in the prognosis
of women with early stage breast carcinoma who are also receiving adjuvant
treatment as well as in women with metastatic breast carcinoma receiving
standard therapy.
- Haematology Characterisation of platelet and plasma von Willebrand
factor variants; clinical studies of transfusion transmitted viral infection in
haemophilia; clinical transfusion studies of new plasma derived products for
the treatment of haemophilia/von Willebrand's disease; data-base studies on
patients with congenital bleeding disorders.
- Clinical pharmacology In vitro simulations of aminoglycoside
concentration-time profiles and effect on gram negative bacterial kill; hepatic
interactions of beta-blockers and calcium antagonists, food effect on drug
bio-availability, heavy metal excretion by the kidney and liver; aminoglycoside
pharmacokinetics: oxygen supplementation and vasodilator use in patients with
cirrhosis, audit of antibiotic prescribing, parenteral nutrition, drug-related
hospitalisations; adverse drug reactions; autonomic and endothelial dysfunction
in cardiovascular disease; effect of drug therapies on gene expression in
cardiovascular disease; cytokine-endothelin interactions.
- Dermatology Melanoma risk in patients with dysplastic naevi,
sunlight in the causation of melanocytic naevi; factors associated with the
development of other melanocytic lesions in Australian schoolchildren;
biological behaviour between different morphological sub-types of basal cell
carcinoma; skin surface microscopy in the early diagnosis of melanoma;
cyclosporin in psoriasis; spironolactone in acne.
- Rheumatology Database development in medicine - the Medical
Diagnostic Index Program ; head shock problems and auto-immune disease;
methotrexate and nonsteroidal anti-inflammatory drug interactions; cyclosporin
and grape fruit juice interactions. Clinical use of chondroprotective agents
(pentosan polysulphate and hyaluronic acid) in osteoarthritis of the knee.
Steroids and bone mineral density in patients with inflammatory rheumatic
diseases.
- Geriatrics Drug usage in the elderly, changes in pharmacokinetics
and pharmacodynamics with ageing, drugs in the causation of falls in the
elderly; dementia; nocturia and incontinence in the elderly; optimal management
and outcomes of hospitalisation in the elderly; circadian rhythms in the
elderly; delirium in the elderly; electrolyte and metabolic disturbances in the
elderly.
- Respiratory disease Asthma - airway inflammation; cytokines and
remodelling and fibrosis of the airways; new drugs; molecular epidemiology;
diet; home environment as modulator of asthma. Physiology - exercise limitation
post lung transplantation; nitric oxide source in the airways and relation to
disease; airway compliance in asthma. CF - new antibiotic regimes; prognostic
indicators; home therapy. Transplantation - PCR for cytomegalovirus,
relationship to outcomes; airway inflammation and relation to non specific
hyperresponsiveness and bronchiolitis obliterans. Use of NO in pulmonary
hypertension. Sleep Medicine - OSA and heart disease. Allergy - T cell cytokine
responses.
- Endocrinology Clinical and experimental thyroidology;
abnormalities of serum binding; endogenous, exogenous and drug competitors for
extracellular and intracellular hormone binding sites; hormone uptake;
regulation of hormone responsiveness in cell culture; studies of the mechanism
of sick euthyroidism and methods of identification of hormone resistance.
Clinical endocrine hypertension. Studies of obesity and weight regulation.
- Palliative care Prospective studies of symptom patterns, their
degree of relief and their prognostic value from time of diagnosis in patients
with incurable cancer; opioid purchasing patterns in tertiary institutions and
impacting variables upon opioid purchasing patterns; collection of baseline
data of neuropathic pains including classification, current practice management
and responses.
Head: Professor M L Wahlqvist
Address: Department of Medicine, Monash Medical Centre, 246 Clayton Road,
Clayton, 3168
Phone: (03) 9550 5525
- Cardiovascular Heart failure - regional sympathetic nerve
activity; the role of cardiac afferents; endogenous vasoactive hormones - ANP,
AVP, ANG II; cardiac arrhythmias and sudden death; regional blood flow at rest
and during exercise; factors influencing exercise tolerance in heart failure;
studies in animal models of heart failure, eg AVP analogues, dopamine agonists;
clinical trials; nitrate-ACE inhibitor interaction; drug treatment of angina;
heart failure in Thalassaemia minor; non-invasive ambulatory blood pressure
monitoring; cardiovascular pharmacology; clinical trials; clinical research:
monitoring progression and regression of atherosclerotic plaques (using B mode
ultra sound scanning) in response to modification of cardiovascular risk
factors - hypertension, hyperlipidaemia, smoking, diabetes; biochemical and
nutritional determinants of angiographically assessed coronary artery disease;
vitamin E (tocopherols and tocotrienols) supplementation in
hypercholesterolaemia; determinants of fatness and coronary risk factor status
in adolescents and adults; comparison of lipoprotein (a) in Anglo-Celtic,
Greek, Chinese and Indian Australians; fish intake and arterial compliance;
food intake in Greek and Chinese Australian pre/post menopausal women and
effect on macrovascular risk factors via hormonal status; dietary changes and
cardiovascular risks in Chinese Australians.
- Clinical nutrition See Cardiovascular, endocrinology,
gastroenterology, respiratory, neurology, immunology, and oncology.
- Public health nutrition Nutritional epidemiology; food intake
methodology; food beliefs and behaviours; food, health and lifestyle profiles
of Anglo-Celtic Australians in Region 8 served by Monash Medical Centre - act
as database and reference group for migrant studies; nutrition and ethnicity
especially of Chinese, Indians and elderly Greeks; co-ordinating department for
international study on food intake and health of elderly in 10 countries;
preventive nutrition; obesity; eating disorders; probiotic foods;
phytochemicals in food of biological significance such as phytoestrogens,
flavonoids, thiosulfinates and residues.
- Body composition Alcoholic cirrhosis; alcohol intake and body
composition in general population; total body nitrogen facility; low dose D20
assay using Fourier transform infrared spectrometry (FTIR); use of
bioelectrical impedance in the young and old; whole body potassium counter;
measurement of bone mineral content and density, and fat and lean mass using
dual energy x-ray absorptiometry (DEXA); distribution of body fat by DEXA,
computerised tomography (CT) scanning and magnetic resonance imaging (MRI);
cystic fibrosis.
- Respiratory Development of fetal cardio-respiratory system and
reflex control of pulmonary circulation; effect of nutrient supplementation on
chronic obstructive pulmonary disease.
- Neurology The role of peptides in the central and peripheral
system, especially in relation to pain; the neuropathology of disorders of
memory; l-dopa containing foods and Parkinson's disease.
- Immunology Nutritional intervention in the aged with
immunodeficiency; nutrition and AIDS; the immunological basis of diseases
including glomerulonephritis, vasculitis and arthritis; immunological
mechanisms of injury in atheroma and other vascular diseases.
- Oncology Nutrition and colorectal cancer (Australian Polyps
Prevention Project).
- Nephrology Pathophysiology of glomerulonephritis, renal
transplantation. Body composition in chronic haemodialysis.
- Gastroenterology GI hormones, gastric function, drugs and peptic
ulcer, lower oesophageal sphincter function, bile acid function; helicobacter
pylori and peptic ulcer disease in Chinese and Anglo-Celtic Australians;
hepatitis; chronic inflammatory bowel disease; nutritional prevention of large
bowel cancer.
- Glomerulonephritis Animal models of crescentic glomerulonephritis;
molecular biology studies of the role of T lymphocytes and cell adhesion; the
role of mediators of thrombosis, particularly tissue factor and its
antagonists, in the evolution of crescentic glomerulonephritis.
- Arthritis Molecular and cellular mechanisms of joint inflammation
in the rat adjuvant arthritis model of human rheumatoid arthritis, and role of
endogenous glucocorticoid modulation of joint inflammation; in vivo studies of
hormonal manipulation and glucocorticoid mediator manipulation in the control
of joint inflammation.
- Rheumatology Clinical studies on Monash Medical Centre
rheumatology patients groups, including studies of novel drug therapies of
rheumatoid arthritis, mobidity studies in systemic lupus erythematosus, and
studies of pain in soft tissue rheumatoid disorders.
- Vascular inflammation The role of immune cells, especially
macrophages, in the development of arthrosclerosis in animal models of lipid
mediated arthrosclerotic vascular disease; in vivo manipulation, cell culture
and molecular biology techniques are used.
- Inflammatory liver disease The role of cells of the immune system
in the mediation of liver injury in hepatitis using in vivo and in vitro
techniques including molecular biology.
Head: Professor H H Salem
Address: Department of Medicine, Box Hill Hospital, Clive Ward Centre, Box
Hill, 3128
Phone: (03) 9895 3540
- Hemostasis (general) Purification and analysis of a novel platelet
activator; analysis of a novel platelet inhibitory mechanism involving
secretory phospholipase A2; structure and function of a new serine proteinase
inhibitor; study of the relationship between apolipoproteins and the protective
effect of estrogens on atheromatous; participating centre in an international,
triple-blind clinical trial of the safety and efficacy of a platelet inhibitor,
Clopidogrel, versus aspirin in patients at risk of ischaemic events (Capri).
- Natural anticoagulants Molecular analysis of thrombomodulin
structure and function; regulation of the thrombomodulin gene in endothelial
cells.
- Fibrinolysis Regulation of the tissue plasminogen activator gene;
regulation of the plasminogen activator inhibitor 2 gene.
- Signal transduction Cell biology, biochemistry and molecular
analysis of enzymes mediating inositol polyphosphate turnover; identification
of proteins interacting with key receptors and phosphoinositol 3 kinase in
platelets; investigation of the role of tyrosine kinases in platelets.
Handbook Contents
| Faculty Handbooks
| Monash University
| Published by Monash University, Clayton, Victoria
3168
Copyright © Monash University 1996 - All Rights Reserved -
Caution
Authorised by the Academic Registrar December 1996
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