Authorised by Academic Registrar, April 1996
Objectives On completion of this subject, students will have an appreciation of the fundamental principles of protein architecture, folding and the structure-function relationship, particularly the control of protein conformation by ligand-binding; an ability to apply these fundamental concepts in understanding the structure and controlled function of the macromolecular assemblies of living cells; understanding of endocrine control of cellular processes; an appreciation of the biochemical perturbations in some important disease states; an ability to plan and execute complex biochemical laboratory procedures with an appropriate degree of competence; demonstrate safe handling of hazardous biological materials and radioisotopes.
Synopsis This subject begins with a study of protein chemistry, including the principles of folding of polypeptide chains, the notion of ligand induced conformational changes as a fundamental control mechanism, and catalysis and its control. The dynamic biochemistry of membranes and the biochemistry of the cytoskeleton are then considered, followed by a study of hormonal control of metabolism. The biochemistry of disease is illustrated by a detailed study of diabetes, cancer and heart disease. Laboratory work is designed to introduce modern analytical procedures and to illustrate key concepts of the theory course.
Assessment Mid-semester test and final examination: 70% + Practical work: 30% + A pass in both theory and practical work is mandatory