Authorised by Academic Registrar, April 1996
Objectives On the completion of this subject students will be able to list the reaction sequences whereby common cellular fuels are catabolised, accompanied by the conservation of biologically useful energy; write the major pathways for amino acid catabolism and the excretion of nitrogen; appreciate the link between energy conservation and biosyntheses; describe the major biosynthetic reaction sequences for carbohydrates, lipids, nucleotides; discuss the integration of metabolic processes to meet the needs of the functioning organism; understand the mechanisms of control of metabolic reaction sequences; demonstrate practical techniques for the isolation and assay of proteins from complex biological mixtures; acquire advanced laboratory skills, in particular data collection/interpretation and report writing.
Synopsis The subject is introduced by a general outline of metabolism and bioenergetics, then continues with cellular oxidation reactions, the electron transport chain, and pathways whereby energy is released from major dietary components: carbohydrate, protein and lipid. A study of photosynthesis illustrates the linkage between electron transport systems and biosyntheses. Other biosyntheses discussed include those of carbohydrates, lipids, and nucleotides. The integration and control of cellular biochemistry is considered. This includes the role of hormones in metabolic regulation .Practical work is an integral component of the subject, emphasising techniques of preparation and assay and illustrating critical aspects of the theory course.
Assessment Mid-semester test and final examination: 70% + Practical work: 30% + A pass in both theory and practical work is mandatory