Authorised by Academic Registrar, April 1996
Objectives On the completion of this subject students should understand cell biology and gene expression; comprehend macromolecular structure and function and cell-matrix interactions; understand intracellular signalling at the molecular level; comprehend organelle formation and function; achieve a broad view of the importance of biochemistry and molecular biology to current advances in biology and medicine; develop skills in the use of routine biochemistry laboratory equipment and in advanced biochemical and molecular biological techniques; manipulate and interpret biochemical data; find information in the scientific literature on particular topics in biochemistry and molecular biology; prepare a substantial written work on a topic in biochemistry and molecular biology; develop skills in the communication of scientific information by verbal, written and poster displays.
Synopsis This subject is presented as five main themes based on cellular and molecular biology: (i) plasma membrane and cytoskeleton - structure and function of the plasma membrane, control of cell shape, cell movement and cell-cell interaction; (ii) biophysics of the cell and its environment - the extracellular matrix, membrane transport, diffusion and osmosis; (iii) signal transduction, cell regulation, development and differentiation - hormones and receptors, second messenger systems, the immune system, apoptosis, regulation of cell growth and the cell cycle; (iv) synthesis and intracellular trafficking of proteins and glycoproteins - post translational processing of secretory and membrane proteins, the biochemistry of lysosomes; (v) formation and function of chloroplasts and mitochondria - cellular bioenergetics, evolution and role in disease and ageing. Practical training extends the student's skill in modern and advanced techniques in biochemistry and molecular biology.
Assessment Essay: 25% + Examinations (2 x 2 hours): 60% + Laboratory: 15%