Faculty of Pharmacy and Pharmaceutical Sciences

Monash University

Undergraduate - Unit

This unit entry is for students who completed this unit in 2015 only. For students planning to study the unit, please refer to the unit indexes in the the current edition of the Handbook. If you have any queries contact the managing faculty for your course or area of study.

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6 points, SCA Band 2, 0.125 EFTSL

Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.

FacultyFaculty of Pharmacy and Pharmaceutical Sciences
OfferedParkville Second semester 2015 (Day)
Coordinator(s)Dr Elizabeth Yuriev


The unit will cover a number of important topics in the area of computational drug design

  1. Structure-based drug design (SBDD): docking, conformational and orientational searching (posing) and scoring methods; applications of SBDD in virtual screening and de novo drug design
  2. Molecular databases: Representations of molecular data, molecular and biological databases.
  3. Molecular properties: Prediction of molecular properties, molecular similarity.
  4. Computational lead optimisation: pharmacophores, molecular interaction fields, experimental design, compound selection, factorial design, Craig plots.
  5. An introduction to bioinformatics and its application to drug development
  6. Protein structure: protein homology and homology modelling


During the course of this unit, students will learn about a number of advanced computational technologies specifically implemented in the pharmaceutical sciences.

Students will be expected to:

  1. Understand selected concepts and techniques underpinning computational drug design
  2. Be able to apply knowledge of these techniques in predicting and evaluating drug-target interactions
  3. Develop their ability to engage with the current literature and critically interpret research publications


End of semester written exam - 60% (2 hr) ; Practical component and computational drug design assignment - 40%

Workload requirements

Contact hours for on-campus students:

  • thirty 1-hour lectures (24 face-to-face lectures plus 6 hours active learning
  • five 4-hour practical laboratories

See also Unit timetable information

Chief examiner(s)


PSC2142 Computational Chemistry

Additional information on this unit is available from the faculty at: