Faculty of Pharmacy and Pharmaceutical Sciences

Monash University

Undergraduate - Unit

This unit entry is for students who completed this unit in 2015 only. For students planning to study the unit, please refer to the unit indexes in the the current edition of the Handbook. If you have any queries contact the managing faculty for your course or area of study.

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6 points, SCA Band 2, 0.125 EFTSL

Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.

FacultyFaculty of Pharmacy and Pharmaceutical Sciences
OfferedParkville Second semester 2015 (Day)
Coordinator(s)Associate Professor Bernard Flynn


This subject aims to provide students with an understanding of:

  1. The use of functional groups in carbon-carbon and carbon-heteroatom bond formation;
  2. The fundamentals of molecular orbitals in pericyclic reactions;
  3. The preparation and use of organometallic in organic synthesis.The synthesis of organic molecules, including naturally occurring bioactives and other drug molecules.

This will involve:

  • functional group manipulation .The chemistry of organometallic reagents.
  • pericyclic chemistry
  • synthesis of heterocycles
  • reactions of aromatic heterocycles
  • synthesis of heterocyclic drugs


At the end of this unit students will be able to:

  1. Draw mechanisms and rationalise the outcome of a range of functional group manipulations;
  2. Rationalise the use of functional groups in organic synthesis;
  3. Understand the use of organometallic reagents in synthesis and their reaction mechanisms;
  4. Understand the role of molecular orbitals in pericyclic reactions;
  5. Apply knowledge of organometallic, pericyclic and heterocyclic reactions to the design of synthetic routes for preparing simple organic compounds.


Final exam (2.5 hour): 50%; Mid-semester assessments: 20%; Practical assessments: 20%; Practical exam:10%.

Workload requirements

Contact hours for on-campus students:

  • Twenty 1-hour lectures
  • Ten 1-hour whole class tutorials / active learning sessions
  • Nine 4-hour laboratory practical exercises, including practical exam

Additional requirements:

  • Twelve hours practical report preparation

See also Unit timetable information

Chief examiner(s)


Additional information on this unit is available from the faculty at: