Monash University Handbook 2010 Undergraduate - Unit

Synopsis

The principle aim of this subject is to provide students with a detailed knowledge of numerous aspects of synthetic organic chemistry, as it applies to modern medicinal chemistry.

The subject follows from PSC2121 and PSC2122, covering advanced organic synthesis and methodology. Topics include catalysis in synthesis, radical chemistry, organometallic chemistry, heterocyclic chemistry, reactive intermediates and stereochemistry, as well as retrosynthetic analysis. An understanding of reaction mechanisms will be emphasized throughout. The practical component reinforces aspects of the lecture course with laboratory experience.

This will involve:

• Catalysis and biocatalysis
• Organometallic reactions
• Radical reactions
• Heterocyclic Chemistry
• Asymmetric Synthesis
• Reactive Intermediates

Objectives

At the end of this unit students will be able to demonstrate:

1. a wider knowledge of synthetic methodology;
2. a knowledge of the use of catalysis in synthetic chemistry;
3. an understanding of radical reactions and their role in synthesis;
4. a broader knowledge of organometallic and heterocyclic chemistry;
5. a broader understanding of asymmetric synthesis and methods for the resolution of stereoisomers;
6. the ability to undertake a retrosynthetic analysis and to design a synthesis of a target molecule;
7. the ability to read and understand the synthetic organic chemistry literature;
8. the practical ability to perform a routine synthesis in the laboratory and experience of most common operations in an synthetic chemistry laboratory;

Assessment

Final exam (2.5 hour): 60%; mid-semester exam: 10%; practical assessments: 20%; practical exam: 10%.

Chief examiner(s)

Dr Jamie Simpson

Prerequisites

VPS2121 Synthetic Chemistry I
VPS2122 Synthetic Chemistry II

Additional information on this unit is available from the faculty at:

http://www.monash.edu.au/muso/support/