Monash University Handbook 2010 Undergraduate - Unit

Synopsis

A description of the advanced tools and methodologies that are used in the determination of reaction mechanisms will be provided. This is supported by a discussion of the theoretical basis of the design of synthetic pathways for target e.g. bioactive molecules. The knowledge gained will be used to elucidate the reaction mechanisms of common organic reactions and metal-mediated reactions towards identifying scope in organic chemistry. The development of chemical methods that allow realisation of the concept of a sustainable future will also be discussed. Advanced NMR spectroscopy will also be introduced as a useful tool to elucidating structure.

Objectives

On completion of this unit students will have gained an understanding of the tools and methodology that are used to study the mechanisms of chemical reactions, gained a broad overview of a range of modern organic synthetic methods and will have developed the ability to design synthetic pathways based on the principles of retrosynthetic analysis. Particular emphasis will be placed on advanced organic transformations, metal-mediated reactions (e.g. Heck, Suzuki, Grubbs) and 'greener' reaction types (e.g. catalysis). Students will gain an understanding of the principles of green chemistry, application of which leads to waste, hazard and energy use reduction, through the study of a series of synthetic examples. Students will also have developed skills in problem solving through exercises on reaction mechanisms; gained generic practical skills and enhanced their report writing skills.

Assessment

Examination (2 hours): 47%
Mid-semester test (1 hour): 23%
Laboratory work and short laboratory reports: 30%
Students must achieve a pass mark in their laboratory work to achieve an overall pass grade.

Chief examiner(s)

Dr David Lupton

Contact hours

Three 1-hour lectures/tutorials and the equivalent of 3 hours of laboratory activity per week

Prerequisites

CHM2911 and CHM2922. Students without these should consult the third year coordinator.