VPS2122 - Synthetic Chemistry II

Leader: Dr Bim Graham

Offered

Parkville Second semester 2008 (Day)

Synopsis

Reactive intermediates and mechanisms. Formation and stabilization. Mechanisms of reactions. Chemistry of heterocyclic compounds. Formation of heterocycles. Substitution of heterocycles. Chemistry of bioactive natural products. Retrosynthetic analysis and synthesis. Metal ions in medicine. Bioavailability of metal ions. Electronic and geometric structures.

Objectives

After completing this unit students will be expected to be able to: describe and rationalise the properties of simple coordination complexes, describe synthetic routes for preparing coordination complexes, explain how a variety of metal-based therapeutic agents work, draw mechanisms and rationalise the outcome of a range of organometallic, pericyclic and heterocyclic reactions, apply knowledge of organometallic, pericyclic and heterocyclic reactions to the design of synthetic routes for preparing simple organic compounds, describe the syntheses of several important heterocyclic drugs, demonstrate the development of synthetic laboratory skills appropriate for a 2nd year student, and demonstrate the development of written communications skills appropriate for a 2nd year student.

Assessment

Practical Exam 10%; Practical Reports 20%; Final Examination (2 hours) 70%.

Contact hours

24 x 1 hr lectures, 12 x 1 hr whole class tutorials, 9 x 4 hr practical classes = 72 hrs.

Off Campus Attendance Requirements

VPS1022 Organic chemistry II, VPS1072 Physical chemistry II.

Prerequisites

VPS1022 Organic chemistry II and VPS1072 Physical chemistry II.