VCP3031 - Pharmaceutics II A

Leader: Dr Joseph Nicolazzo

Offered

Parkville First semester 2007 (Day)

Synopsis

Drug metabolism. IV infusion and multiple dosing. Haemodialysis and modified release formulation. Drug pharmacokinetics in hepatic and renal failure. Protein binding and drug pharmacokinetics. Pharmaceutical and pharmacokinetic calculations.

Objectives

Students will develop an:

• Understanding of the use of pharmacokinetics to direct the appropriate administration of drugs, particularly intravenous infusions and multiple dose administrations.
• Appreciation of the impact of modified release oral and parenteral formulations on the pharmacokinetics of drugs, and of the impact of haemodialysis on drug therapy.
• Understanding of drug metabolism, in general, focussing on clinical relevance.
• Understanding of hepatic and renal elimination of drugs and the change to drug pharmacokinetics observed in hepatic and renal failure.
• Ability in the areas of performing pharmaceutical and pharmacokinetic calculations.

Assessment

Written examination: 100% (2 hours). Satisfactory performance in practical work is required.

Contact hours

17 Lectures; Practicals / Workshops 4 x 3hrs including on-line delivery.

Prerequisites

All 2nd year Bachelor of Pharmacy units