VCF3081 - Toxicology I

Leader: Dr. John Haynes

Offered

Parkville First semester 2007 (Day)

Synopsis

Basic pharmacological mechanisms. Absorption, transformation, distribution, metabolism, pharmacokinetics, bioavailability and pharmacodynamics of xenobiotics. Mechanisms of toxicological insult as well as effects of xenobiotics on the blood, skin, liver, kidneys and the immune, respiratory, nervous, cardiovascular, reproductive and endocrine systems. Carcinogenesis, pesticides, heavy metals, solvents, animal toxins, plant toxins and ecotoxicology

Objectives

Students will develop an idea of general pharmacological principles and methods used in establishing pharmacological actions of xenobiotics. The specific objectives are to:
Identify how chemical mediators undergo absorption, metabolism and distribution across body compartments to access sites of action.
Learn the general principles of pharmacology and toxicology through application to major organ systems.
Utilize a pharmacological approach to establishing sites of drug and xenobiotic action

Assessment

Examination (2 hours)

Prerequisites

All of 2nd year B.Form. Sci units