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BMC3021 - Synthetic Medicinal Chemistry

6 points, SCA Band 2, 0.125 EFTSL

Undergraduate Victorian College of Pharmacy

Leader: Dr Jamie Simpson


Parkville First semester 2007 (Day)


The subject follows from BMC2021 and BMC2022, covering advanced organic synthesis and methodology. Topics include catalysis in synthesis, radical chemistry, organometallic chemistry, heterocyclic chemistry, reactive intermediates and stereochemistry, as well as retrosynthetic analysis. An understanding of reaction mechanisms will be emphasized throughout. The practical component reinforces aspects of the lecture course with laboratory experience.


At the completion of this unit the student will have:

  1. A wider knowledge of synthetic methodology;
  2. A knowledge of the use of catalysis in synthetic chemistry;
  3. An understanding of radical reactions and their role in synthesis;
  4. A broader knowledge of organometallic chemistry;
  5. A broader understanding of heterocyclic chemistry;
  6. A broader understanding of asymmetric synthesis and methods for the resolution of stereoisomers;
  7. The ability to undertake a retrosynthetic analysis and to design a synthesis of a target molecule;
  8. The ability to read and understand the synthetic organic chemistry literature;
  9. The practical ability to perform a routine synthesis in the laboratory;
  10. Experience of most common operations in an synthetic chemistry laboratory;


End of semester exam (3 hours) 60%, Mid semester exam 10%, Practical Class 30%


BMC2021, BMC2022